Lecturer： Dr. Vasudevan Ramesh
School of Chemistry the
Learning objectives
Understanding the NMR experimental parameters which govern the quality of resultant NMR spectra
To elaborate on the principles and experimental methods involved in the acquisition, data processing and interpretation of one- and two-dimensional NMR spectra
To demonstrate the application of NMR in elucidating structures with suitable examples
Syllabus
Basic principles of NMR and experimental parameters,
1H,
Relationship between the NMR spectrum and molecular structure
Spin–spin coupling; H-H, C-H coupling constants; Karplus relationship
Analysis of NMR spectra; nomenclature of spin systems
Fourier transformation; sensitivity enhancement; nuclear relaxation
Multipulse NMR techniques; DEPT experiment
Two-dimensional NMR; chemical shift correlation (COSY, TOCSY, HMQC and HMBC)
The Nuclear Overhauser Effect; 1D NOE , 2D NOESY and ROESY
NMR Applications; dynamic NMR
Intended learning outcomes
Demonstrate an understanding of the NMR phenomenon and its applications
Explain the significance of chemical shifts (1H,
Describe the physical basis of spin-spin coupling
Exemplify how coupling constants can be used to determine stereochemical relationships
Show how enhancement of sensitivity takes place due to Fourier transformation
Explain the utility of multipulse NMR in spectral simplification
Describe in a simple way how 2D NMR works and the different types of experiments that can be performed
Rationalise the NOE effect ( 1D and 2D ) to solve organic structural problems
Demonstrate how NMR can be applied to investigate dynamic effects ( e.g. barriers to rotation etc)
时间：
地点：国重2号楼2层报告厅
Dr. Vasudevan Ramesh是重点室的客座教授，多年从事NMR工作，经验丰富。这次系列讲座内容广泛，包括NMR的基础知识和高级应用。欢迎对核磁共振波谱感兴趣的老师、同学参加。还有继续教育学分！
天然药物和仿生药物国家重点实验室
2012.04.06
